Immune Repertoire Sequencing

Immune Repertoire refers to the set of all functionally diversified B cells and T cells in a person's circulatory system. Immune repertoire sequencing (Immuno-Seq) targets T/B lymphocytes and utilizes the 5’ Rapid Amplification of cDNA Ends (RACE) Technology. The 5’ RACE technology amplifies complementarity-determining regions (CDRs) of B cell receptors (BCRs) or T cell receptors (TCRs). The CDRs are targeted because they control the diversity of the corresponding BCRs and TCRs. Combined with high-throughput sequencing technology, the Immuno-Seq provides a comprehensive evaluation of the immune system diversity.